Rtog 0915, a randomized phase ii study comparing 2 stereotactic body. Rtog 0630 radiation therapy oncology group rtog 0630 a phase ii trial of image guided preoperative radiotherapy for primary soft tissue sarcomas of the extremity study chairs principal investigatorradiation oncology surgical oncology cochair dian wang, md, phd john m. Safe regimen with effective palliation of symptoms. The phase ii component of rtog 0631 assessed the feasibility and safety of spine radiosurgery srs for localized spine metastases in a cooperative group setting. No other use or reproduction is authorized by rtog nor does rtog assume. Randomized phase iii trial to test accelerated versus standard fractionation in combination with concurrent cisplatin for head and neck carcinomas in the radiation therapy oncology group 0129 trial. Stereotactic body radiation therapy for inoperable early stage.
Challenging situations for lung sbrt journal of thoracic oncology. Additional definitions beyond the recist guidelines. From wikibooks, open books for an open world rtog 0232. Bruner d, scott c, mcgowan d, et al validation of the sexual adjustment questionnaire saq in prostate cancer patients enrolled on radiation therapy oncology group studies 9020 and 9408. Management of prostate cancer a riskbased approach anthony v. Radiation therapy oncology group rtog 0618 a phase ii. Implementation of radiosurgery and sbrt requires a. Kane iii, md medical college of wisconsin roswell park cancer institute.
Sorafenib tosylate with or without stereotactic body. Abt414 shows no overall survival benefit for patients with newly diagnosed glioblastoma trastuzumab does not negatively impact cardiac function for women with breast cancer in longterm followup. May 16, 2016 nrg oncology rtog 6 a randomized phase ii study of individualized combined modality therapy for stage iii nonsmall cell lung cancer nsclc. Pdf complications from stereotactic body radiotherapy for lung.
Rtog 0631 radiation therapy oncology group rtog 0631 phase iiiii study of imageguided radiosurgerysbrt for localized spine metastasis study chairs principal investigatorradiation oncology samuel ryu, md henry ford hospital 2799 w. Videtic and others published radiation therapy oncology group rtog protocol 0915. Patients with spine metastasis with a numerical rating pain scale nrps score. Whole breast irradiation 2d radiotherapy fluoroscopic simulation central plane dosimetry. The protocol specified a 7mm expansion on these volumes to generate a planning target volume ptv, and 50. Pelvic irradiation with concurrent chemotherapy versus pelvic. Nov 21, 2012 distributions of qol data collection patterns over all collection points in each treatment arm will be described.
Rtog 4 ulceration, bleeding, necrosis rarely seen rtog assessment tool and intervention rationales please can you ensure that all patients on discharge are given one weeks supply of the dressings they are on. Dose tolerance limits and dose volume histogram evaluation for. Rtog 0915 nrg oncology rtog 0915 ncctg n0927 a randomized phase ii study comparing 2 stereotactic body radiation therapy sbrt schedules for medically inoperable patients with stage i peripheral nonsmall cell lung cancer document history 3614 versionupdate date broadcast date amendment 4 march 6, 2014 march 19, 2014. Rtog 0915 12gy x 4 vs 30gy x 1 showed equivalent control. A randomized, phase iii, doubleblind, placebocontrolled trial of memantine for prevention of cognitive dysfunction in patients receiving wholebrain radiotherapy nadia n. Sep 21, 2015 is it reasonable to omit adt in the setting of doseescalated radiotherapy for patients with intermediaterisk prostate cancer. Rtog 9202 70 gy 1992 to 1995 t2c4 psa preop chemoradiotherapy crt utilizing imrt in. Rtog 0529 radiation therapy oncology group rtog 0529 a phase ii evaluation of dosepainted imrt in combination with 5fluorouracil and mitomycin.
Pdf stereotactic body radiotherapy sbrt has become a standard treatment option. Pathologically histologically or cytologically proven diagnosis of squamous cell carcinoma including the histological. Radiation therapy oncology group rtog 0618 a phase ii trial. To compare the efficacy of moderateduration 28week neoadjuvant total androgen suppression and rt with shortduration 8week neoadjuvant total androgen suppression and rt as related to diseasespecific. A phase iii study comparing combined external beam radiation and transperineal interstitial permanent brachytherapy with brachytherapy alone for selected patients with intermediate risk prostatic carcinoma. Damico, md, phd, fastro professor of radiation oncology harvard medical school. Cisplatin and etoposide, every 4 weeks, for 2 cycles.
This site will allow users to register a patient or enter case form data directly to a nrgrtog study twentyfour 24 hours a day, seven 7 days a week. Radiation therapy oncology group rtog 0618 a phase ii trial of stereotactic body radiation therapy sbrt in the treatment of patients with operable stage iii nonsmall cell lung cancer study chairs 2409 principal investigatorradiation oncologyigrt robert d. Standarddose versus highdose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage iiia or iiib nonsmallcell lung cancer rtog 0617. Rtog is a participant in national cancer institute research through nrg oncology. Radiation oncologyrtog trials9910 wikibooks, open books. To compare the efficacy of moderateduration 28week neoadjuvant total androgen suppression and rt with shortduration 8week neoadjuvant total androgen. Comparison of two rapidarc delivery strategies in stereotactic. Rtog 0631 phase iiiii study of imageguided stereotactic.
Radiation therapy alone r for all s egfr expression r rt, 2 gyday, in 30 fractions e patients. Radiation oncologycervixrtog cervix wikibooks, open. If you would like to utilize this site to register a patient and have not been assigned a login name and password from nrgrtog headquarters, please access the password. This protocol was designed and developed by the radiation therapy oncology group rtog of the american college of radiology acr. Rtog 0236 a phase ii trial of sbrt in the treatment of patients with medically inoperable stage iii nonsmall cell lung cancer rtog 0618 a phase ii trial of sbrt in the treatment of patients with operable stage iii nonsmall cell lung cancer rtog 08 seamless phase iii study of sbrt for early stage, centrally. Rtog is funded by national cancer institute grant numbers. Radiation oncologyrtog trials9408 wikibooks, open books. Chen gp, liu f, white j, vicini fa, freedman gm, arthur dw, li xa. A phase iii dose intensification study using three dimensional conformal radiation therapy and concurrent chemotherapy for patients with inoperable, nonsmall cell lung cancer objective. Radiation oncologyrtog trials wikibooks, open books for an.
International journal of radiation oncology, biology, physics 42suppl 1. Pmid 2476426, 1989 phase ii study of multiple daily fractionations in the palliation of advanced pelvic malignancies. Rtog 0938 nrg oncology122214 rtog 0938 a randomized phase ii trial of hypofractionated radiotherapy for favorable risk prostate cancer schema s t r a t i f y treatment techniquesmachine 1. A randomized phase iii clinical trial evaluating postmastectomy chestwall and regional nodal xrt and postlumpectomy regional nodal xrt in patients with positive axillary nodes before neoadjuvant chemotherapy who convert to pathologically negative axillary nodes after neoadjuvant chemotherapy. The worlds most comprehensive professionally edited abbreviations and acronyms database all trademarksservice marks referenced on this site are properties of their respective owners. This is an area of considerable debate and the topic of an ongoing north american cooperative randomized trial radiation therapy oncology group rtog 0815 for patients with intermediaterisk prostate cancer clinical stage t2b or t2c, gs of 7, or psa of 1020. Primary study endpoint analysis for nrg oncologyrtog 08 trial of stereotactic. A randomized phase 2 study comparing 2 stereotactic body radiation. Assessment observation effects of radiotherapy on skin cells rationale rtog 0 no visible. Creation of rtog compliant patient ctatlases for automated atlas based contouring of local regional breast and highrisk prostate cancers. Review of primary data from trials covering hyperbaric oxygen, altered fractionation, hypoxic cell sensitization, chemosensitization, prophylactic pa irradiation, and neutrons. Nvcr announced today that the first patient has been enrolled in the rtog foundations phase 2 pilot trial testing optune together with bevacizumab for patients with bevacizumabrefractory recurrent glioblastoma gbm. Treatment of peripheral nonsmall cell lung carcinoma with. May 01, 20 rtog 0418 specified that the pelvic lymphatics were contoured according to rtog guidelines.
Paclitaxel and carboplatin weekly for 6 weeks followed by 2 cycles of consolidation. Nrg oncology rtog 6 a randomized phase ii study of. The vaginal internal target volume was created with use of a full and empty bladder scan. Pelvic irradiation with concurrent chemotherapy versus. Rtog 0236 a phase ii trial of sbrt in the treatment of patients with medically inoperable stage iii nonsmall cell lung cancer rtog 0618 a phase ii trial of sbrt in the treatment of patients with operable stage iii nonsmall cell lung cancer rtog 08 seamless phase iii study of. Chisquared tests will be used to test the null hypothesis that the proportion of patients categorized as improved will be the same for the 2 treatment arms, versus the alternative hypothesis that the proportion of patients categorized as improved is higher for the sbrt. The rtog 3503 phase 2 pilot trial is the first consortium study to test treatment with optune st. The rtog 0915 protocol utilized a more conservative dmax of 27. Radiation oncologypalliationpelvic wikibooks, open. Is it reasonable to omit adt in the setting of doseescalated radiotherapy for patients with intermediaterisk prostate cancer. All linear accelerator based treatment excluding cyberknife 2.
Radiation oncologytoxicity gradingrtog wikibooks, open. This is an area of considerable debate and the topic of an ongoing north american cooperative randomized trial radiation therapy oncology group rtog 0815 for patients with intermediaterisk prostate cancer clinical stage t2b or t2c, gs of 7, or psa of 1020 ngml. Nrgalias broadcasts rtog clinical trials protocol table. Damico, md, phd, fastro professor of radiation oncology. It is intended to be used only in conjunction with institutionspecific irb approval for study entry. Rtog 0418 specified that the pelvic lymphatics were contoured according to rtog guidelines. Rtog 1016 phase iii trial of radiotherapy plus cetuximab. After 20 years of rtog trials, conventional radiation therapy had progressed to the point. The radiation therapy oncology group rtog 0236 trial was the first. All the plans met the dose constraints described in the rtog 0915 protocol. A planning comparison of 7 irradiation options allowed in rtog 1005 for earlystage breast cancer. Stereotactic body radiotherapy for centrally located stage i nonsmall. Pdf creation of rtog compliant patient ctatlases for. Currently, the radiation therapy oncology group rtog, supported by the national cancer institute nci, is conducting a prospective clinical trial to investigate the impact of preoperative, advanced imageguided radiation technology igrt on radiationrelated toxicities in patients with extremity soft tissue sarcoma.
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